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Chest 140, 580–585

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Upon stimulation by inflammatory signals such as TNF-α and IL-1, vascular endothelial cells undergo activation, during which they release chemotactic signals (e.g., CXCL8, CXCL12, complement C5a, and platelet-activating factor) and upregulate surface adhesion molecules, thus facilitating the transmigration of leukocytes into tissues [189,190]