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The MAMs serve several functions, one of which being that the SR and mitochondria can transfer Ca 2+ at MAMs [Figure 4 ( 2+ in response to caffeine stimulation ( 2+ regulate multiple mitochondrial enzymes ( 2+ can increase maximum velocity of oxidative phosphorylation by activating many aspects of the oxidative phosphorylation pathway ( 2+ and less Ca 2+ transport into the mitochondria ( Absence of SELENON in mice resulted in decreased mitochondrial respiratory capacities in the tibialis anterior, diaphragm, and quadriceps muscles compared to wild-type mice (Figure 4 ( SELENON knockout mice have lower blood glucose and faster muscle and liver glycogen depletion in response to exercise (Figure 1)

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Orthosiphon stamineus (OS) Benth., also known as Misai Kucing, is a medicinal herb in the Lamiaceae family, native to Southeast Asia