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Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules

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Alternative routes are available, however, to synthesize methionine from betaine and 5-MTHF via betaine-homocysteine methyltransferase (BHMT), although this route is limited to the liver and kidney [7]