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Multiple transcription start sites and alternative splicing events generate two protein isoforms (70 and 77 kDa) and heterogeneous mRNA 5' and 3'untranslated regions (UTRs), reflecting complex transcriptional control
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Molecular docking experiments had found that pseudo-Berberine (IMBY 53) had a lower affinity for P-gp, enhancing its blood sugar-lowering effect by prolonging its retention time in hepatocytes and muscle cells ( Ding et al
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