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Detection of D-aspartate in tau proteins associated with Alzheimer paired helical filaments
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Several studies have been previously shown mechanisms of action of hydroxycholorquine (HCQ) in alleviating OA conditions and delaying progression via inhibition of TLRs and modulation of the immune response, reduction in TNF-α and IL-1, and downregulation of NF-κB, a key transcription factor involved in inflammation and cartilage degradation
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