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ejection s’s high-pitched clicking sounds heard very shortly after the first heart sound, attributed to sudden distention of a dilated pulmonary artery or aorta or to forceful opening of the pulmonic or aortic cusps

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These compounds can interact with the amino acid residues of proteins, mainly histidine, cysteine, and lysine, to form carbonyl derivatives known as advanced lipoxidation end-products (ALEs) (169)