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By suppressing cytotoxic CD8+ T-cells, expanding regulatory T cells, and promoting myeloid-derived suppressor cells (MDSCs), VEGF facilitates tumor immune evasion ( The VEGF signaling axis is heterogeneous, comprising multiple ligands (VEGF-A, -B, -C, -D, and placental growth factor) and receptors (VEGFR-1, -2, -3) as well as co-receptors such as neuropilins ( + T cells, expanding regulatory T cells, and increasing myeloid-derived suppressor cells (MDSCs), VEGF promotes tumor immune evasion—mechanisms corroborated in translational studies and consistent with the synergy observed when VEGF blockade is combined with immune checkpoint inhibitors (Figure 1)
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