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BHB is a ketone body used as alternative energy source in metabolic states of energy depletion, such as those simulated by the experimental concentrations starting at 1 mM BHB [107]

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Senescent cells persist in lung tissue and release multiple inflammatory mediators, known as the senescence-associated secretory profile (SASP), which spreads senescence and is very similar to the pattern of mediators that are increased in COPD [19]