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We also demonstrate the utility of HRMS discovery-based approach (sometimes referred to as pharmacometabolomics in clinical applications ( 35, 36 )) to advance a step forward towards precision and personalized medicine and uncover new metabolites markers that can be used to provide better typing of patients related to the kinetic of elimination of a drug or to identify inter-individual susceptibility to develop drug-induced liver injury, as it is the case here with APAP

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