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The structure of the GPX4 monomer lacks an internal extension of 20 amino acids that is conserved in the tetrameric GPX enzyme, which encodes a loop around the active site to prevent the entry of complex substrates into the active site [8]

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However, in scurvy, vitamin C is retained by the brain for neuronal function, and eventual death from the disease is more likely due to lack of vitamin C for collagen synthesis (44)