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Unlike these agents, which are specifically engineered to accumulate within mitochondria through defined targeting strategies [either via membrane potential-driven uptake (TPP-conjugated antioxidants) or cardiolipin-binding motifs (Szeto-Schiller-peptides)] LYC lacks a dedicated mitochondrial delivery mechanism ( 5 Conclusion Collectively, the preclinical literature supports that LYC is a multi-modal mitochondrial protector that modulates redox balance, stabilizes OXPHOS, limits mitochondria-mediated apoptosis, and influences mitochondrial quality control
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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Blaser H., Dostert C., Mak T.W., Brenner D