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In humans, it has been observed that mtDNA duplications can be maternally inherited and that these duplicated molecules generate deletions by intramolecular recombination within postmitotic tissues (Wallace and Fan 2009)

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The Nosé–Hoover thermostat 92,93 and Parrinello–Rahman barostat 94 were used to keep the systems at 320 K and 1 bar