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In view of the pivotal role that macrophage polarization plays in the context of liver inflammation, there is a clear necessity for further research in this area to be conducted
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Chemosensitivity can be determined by FISS tissue γH2AX immunohistochemistry that can indicate DNA damage, as γH2AX expression might be useful to determine chemosensitivity (Kang et al., 2017), but further studies are needed